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pentobarbital will decrease the level or influence of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.pentobarbital will lower the extent or outcome of duvelisib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with a powerful CYP3A induce